– Researchers Challenge Fundamental Principles of Molecular Neuroscience

Scientists have discovered that learning and memory rely on the structural, not enzymatic, functions of the CaMKII enzyme. This breakthrough could lead to new treatments for Alzheimer’s and possibly Down syndrome, by using inhibitors that specifically target the enzyme’s enzymatic activity without affecting learning and memory.

But a team of researchers led by Ulli Bayer, Ph.D., professor of pharmacology at the University of Colorado School of MedicineThat’s significant, Bayer said, because it opens the door to the therapeutic use of a new class of inhibitors that target only the enzymatic activity of CaMKII, but not the structural functions required for memory and learning.

The researchers found one group of inhibitors that protected from the Abeta effects without impairing LTP, making it potentially useful in treating a number of brain diseases without debilitating side effects. Bayer said if the inhibitors work in humans, they could provide additional benefits in conjunction with any current AD treatment strategies.

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