Researchers discover a key failure in AMD that may lead to progression and vision loss

📆 9/11/2023 11:15 PM
📰 medical_xpress

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Research led by Nicolas Bazan, MD, Ph.D., Boyd Professor, Ernest C. and Yvette C. Villere Chair for the Study of Retinal Degeneration, and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, suggests that age-related macular degeneration (AMD) decreases an essential fatty acid, preventing the formation of a class of protective molecules and reducing repair potential. The discovery may also open new therapeutic avenues for AMD. The findings are published in Experimental Eye Research.

22:6 in rod photoreceptor cells, limiting the elongation of fatty acids to form very-long-chain polyunsaturated fatty acids . VLC-PUFAs are precursors of elovanoids, bioactive chemical messengers made from omega-3 very- long-chain polyunsaturated fatty acids.

"Biosynthetic fatty acid pathway insufficiencies may be a fundamental factor in the onset and progression of macular degenerative diseases leading to blindness," notes Dr. Bazan."These findings open important immediate avenues for therapeutic exploration for AMD."

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