metabolism in fat tissue. It also increases energy expenditure by accelerating the browning of white fat tissue.
Past research has shown that irisin is present in human and mouse brains. Its levels are lower in patients with“First, we found that irisin treatment led to a remarkable reduction of amyloid beta pathology,” said study author Se Hoon Choi, of the Genetics and“Second, we showed this effect of irisin was attributable to increased neprilysin activity owing to increased levels of neprilysin secreted from cells in the brain called astrocytes," he said in a hospital news release.
Neprilysin is an enzyme that degrades amyloid beta. Elevated levels have been found in the brains of mice with Alzheimer's that were exposed toResearchers were able to take this further by identifying the process that triggers cells to increase neprilysin levels. In mice, irisin injected into the bloodstream can make its way into the brain, making it potentially useful as a therapeutic.
“Our findings indicate that irisin is a major mediator of exercise-induced increases in neprilysin levels leading to reduced amyloid beta burden, suggesting a new target pathway for therapies aimed at the