New Study: Hormone Therapy May Cause Heartburn, Difficulty Swallowing, and Chest Pain

A new meta-analysis indicates a significant association between hormone therapy usage and increased risk of gastroesophageal reflux disease , especially with estrogen use or combined estrogen-progestogen therapy, based on five studies involving over one million participants.

For years, there has been an ongoing debate about the potential connection between hormone therapy and a heightened risk of gastroesophageal reflux disease . A recent systematic review and meta-analysis aims to settle this debate, indicating a notable link between past or present HT use and GERD. The findings of this study were recently published inGERD is one of the most common conditions in gastroenterology practice. Its global prevalence has been estimated at nearly 14%.

All five studies reported a significant association between estrogen use and GERD, as well as between GERD and HT containing a combination of estrogen plus a progestogen. Women who received combined estrogen-progestogen therapies had a lower risk of GERD symptoms compared with HT containing estrogen alone or progestogen alone.

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