Fresh discoveries about a type of immune cells could give lung cancer patients a more accurate prognosis and better identify who will benefit from immunotherapies.
Experts caution, however, that further research and tests are needed alongside the integration of new technologies before any application in clinical practice is possible. Immunotherapies work by boosting the activity of cytotoxic T cells, which play a key role in patrolling the body to detect and kill cancer cells, but often become 'exhausted' when battling tumours.As tumours grow they use complex mechanisms to escape destruction, including interfering with the activity of immune cells, such as T cells.
T cells have an in-built safety mechanism designed to stop them from becoming overactive when fighting an infection. By raising the levels of these enzymes, tumours exploit this and escape destruction.
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