Study suggests the right dietary fat could help boost platelet counts

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Aside from transfusions, there currently is no way to boost people's platelet counts, leaving them at risk for uncontrolled bleeding. Could something as simple as a dietary change raise platelet counts in people with low levels, such as cancer patients receiving chemotherapy?

In contrast, mice fed a diet high in saturated fatty acids had decreased platelet counts. Results were published online in July in"We were honestly surprised at how profound the effects were," says Machlus, whose lab focuses on studying platelets and theirBut equally interesting is the apparent reason for the dietary effect.when they form platelets," Machlus says."We thought the membrane must have an unusual composition to make it so fluid."and hard to access.

In culture, the megakaryocytes with higher amounts of PUFAs in their membrane made more platelets. When the cells were instead supplied with saturated fats as their lipid source, platelet production declined. The same thing happened when the team added compounds to inhibit uptake of PUFAs from the blood.

 

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