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Most Alzheimer's Patients May Be Ineligible for Newly Approved Drugs

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Two recently approved treatments offer newfound hope for patients in the early stages of Alzheimer’s disease, but most people who could benefit will likely be deemed ineligible, a new study finds.

When those were factored in, the researchers discovered only 8% of the study participants would have been eligible for the Leqembi trial.

For Aduhelm , 44% of participants would have met the required characteristics, but after excluding for certain health issues, just 5% would have been eligible. He noted a consensus that's building in the field -- that appropriate use of medications should in many ways mirror the conditions under which the drug was tested in clinical trials.

The study offers very important information for clinicians, that a lot of the people who may seem eligible or may request treatment will not really be appropriate candidates for treatment, said Dr. Stephen Salloway, founding director of the Memory andSalloway is co-author of an editorial accompanying the study findings. Both were published Aug. 16 in the journalAmong the exclusions, Salloway noted that there is no evidence Leqembi works for people in the later stages of Alzheimer's disease.

 

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