Overview of the Dog10K collection. a Sample collection and sample filtering for the varied demographic, genome function, and architecture examined in the program. QC, quality control. ROH, runs of homozygosity. OMIA, Online Mendelian Inheritance in Animals. Credit:An international research consortium has generated and analyzed 2,000 canine genomes.
A catalog of structural variants. This category of variants has a minimum size of 50 base pairs, and so impacts more space in the genome than a single nucleotide. Some structural variants were found to impact protein coding genes. This could mean that too much, or too little of the protein is made in that individual, but again did not cause obvious disease in the pedigree population.
Publicly available data processing pipelines. Combining the results from different studies can be made more difficult when different settings are used to map sequencing data, and then to call variation. The pipeline used by the Dog10K consortium is open to the community so that new or existing data can be processed and easily combined with this set.