By Neha MathurAug 16 2023Reviewed by Sophia Coveney In a recent article published in PLOS One, researchers conducted a cross-sectional study to investigate the association between dietary magnesium intake and peripheral arterial disease , a chronic atherosclerotic disease primarily affecting the lower extremities.The study was carried out using deidentified and publicly available data from the National Health and Nutrition Examination Survey survey.
Nonetheless, magnesium plays a crucial role as a physiological regulator of vascular tone. Previous studies have shown that low serum magnesium leads to a metabolic imbalance in patients with diabetes, increasing the risk of PAD. Related StoriesFurther, they divided the dietary magnesium intake into four quartiles, with Q1 to Q4 indicating magnesium intake between ≤179.00mg and >343.00mg.
Results The researchers performed an ABI test on all NHANES participants aged ≥40, totaling 9,970 individuals. After exclusions for missing covariate and bilateral ABI data, the final analysis sample comprised 5,969 participants. Of these, 409 and 5,560 individuals constituted the PAD and the non-PAD group, respectively.
This association remained significant in people of non-white ethnicities, people with no comorbidities, and who never or formerly smoked. Furthermore, the study analysis revealed a possible interaction between dietary magnesium intake and age.
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