NIH announces long covid treatment studies with hundreds of patients

· Reducing excessive sleepiness and sleep disturbances.

The first of the clinical trials, which will test a longer regimen of the antiviral medication Paxlovid on people with viral persistence, is underway. Doctors have found in some cases that the virus persists in patients for as long as 280 days after infection. NIH acting director Lawrence A. Tabak called the trials, which will receive funding until they are completed, “a significant milestone” and said they will be carried out at institutions with a record of attracting diverse participants.“We’re moving a little in the right direction, but I was underwhelmed,” said Ezekiel J. Emanuel, an oncologist and bioethicist at the University of Pennsylvania, who has previously criticized NIH for not starting the clinical trials sooner.

Researchers “don’t understand whether the symptoms are related to one another,” said Upinder Singh, a professor of infectious disease at Stanford Medicine and co-principal investigator for a Paxlovid clinical trial. “We don’t fully understand why some patients get brain fog and other patients have sleep disturbances.”

Koroshetz said some studies have suggested that 5 percent to 10 percent of people in the United States infected with the coronavirus go on to have long covid symptoms, with the frequency higher in earlier versions of the virus than more recent variants. So far, an estimated 77.5 percent of Americans have been infected with the coronavirus.of nearly 5 million U.S.

Until now, the research sponsored by RECOVER has been observational — meaning it has sought to describe long covid. In contrast, clinical trials test possible interventions, finding out whether treatments are safe and effective.Patient advocates and some researchers have been impatient for NIH to begin the clinical trials, arguing they should have begun long before now.

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