, could contribute to the development of new diagnostic tests, or even treatments, for dementia-causing diseases.“We’re seeing so much involvement of the peripheral biology decades before the typical onset of dementia,” says study author Keenan Walker, a neuroscientist at the US National Institute on Aging in Bethesda, Maryland.
The researchers found 32 proteins that, if dysregulated in people aged 45 to 60, were strongly associated with an elevated chance of developing dementia in later life. It is unclear how exactly these proteins might be involved in the disease, but the link is “highly unlikely to be due to just chance alone”, says Walker.
Walker says that although a person’s proteome by itself cannot predict their risk of getting dementia, it could perhaps bolster the strength of existing predictors — such as age and family history.As expected, some of the proteins that researchers identified are active in the brain — but most have other roles in the body. A handful were linked to proteostasis — the process of carefully balancing protein levels in the proteome.
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