Study links menopausal hormone therapy to increased risk of dementia and Alzheimer's

By Dr. Sanchari Sinha Dutta, Ph.D.Jul 3 2023 A study of Danish women aged 50 – 60 reveals that continuous and cyclic menopausal hormone therapy can increase the risk of dementia and Alzheimer’s disease.Study: Menopausal hormone therapy and dementia: nationwide, nested case-control study. Image Credit: Image Point Fr / Shutterstock

Studies investigating the effect of menopausal hormone therapy on dementia risk have produced contradicting results. While some studies have shown a positive association between estrogen hormone therapy and the risk of dementia, some have reported no such association. Related StoriesThe data on first-time dementia diagnosis or first-time prescription of dementia-specific medications were collected from National Registries to identify cases with all-cause dementia.

Before the first diagnosis of dementia, about 32% of cases and 29% of controls had received combined estrogen-progestin hormone therapy. About 66% of them had treatment cessation more than 8 years before dementia diagnosis. About 8.7% of them were still undergoing treatment at the time of diagnosis. Association between hormone therapy and risk of dementia A higher risk of developing all-cause dementia was observed among participants who had received menopausal estrogen-progestin therapy compared to those who had never received hormone therapy. A similar association was observed for participants with late-onset dementia or Alzheimer’s disease.

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