To investigate the impact of age on NCAs, Pethő and her colleagues analysed a register of births and stillbirths involving congenital conditions that had been kept in Hungary between 1980 and 2009, as well as abortions that had been carried out
because of such conditions. They excluded cases with chromosomal anomalies and milder NCAs, such as hernias.Get the most essential health and fitness news in your inbox every Saturday.The researchers also looked at the total number of live births – nearly 3 million over the period studied – and broke it down by the mother’s age at birth to calculate the risk of having a baby with an NCA at every age. Overall, about 1 in 100 of the babies would have had one of the conditions.
A genetic condition that sees children develop almost no teeth or sweat glands can now be treated by injecting a protein into the amniotic fluid, in just one of a number of new therapies that act before a child is even born They found that the chance of an NCA was lowest in the women aged between 23 and 32. In those older than that, there was a 15 per cent higher chance of such a birth, while there was a 20 per cent higher chance in the younger women.
In women older than 32, the chance of NCAs may be higher because their eggs are older, says Pethő, although in women younger than 23, the higher risk may be because they are more likely to smoke, take drugs and drink, although the study didn’t investigate causes., vice-president for academia and strategy at the UK’s Royal College of Obstetricians and Gynaecologists. However, “the risks to the babies born to mothers outside of the [23 to 32] age range are still small”, she says.
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