The authors could try adding a random slope term for age change in their models and plot the extracted slopes as a separate figure in supplementary. Such random slope terms could also help interpret the interaction effect between baseline LSNS and age change.
Concerning the link between change in age and LSNS we indeed found a statistically significant effect of age change on higher social isolation in an ancillary LME. However, as the reviewer noticed, the per year effect is very small, meaning that it would need getting more than 20 years older to score one point higher on the LSNS sum score . We therefore tend to agree that in our sample, higher age does not affect social isolation substantially.
The authors should consider an ancillary LME with age change predicting LSNS change, and presenting individual slopes in LSNS across time , to visualize how many older adults showed increased loneliness. Thank you very much for your careful reading of our code and this helpful comment. We recalculated our analyses having standardized the data according to your recommendation and found the results to be almost unaffected . Therefore, we decided to stick to our original standardization procedures for the analyses in the main text, to adhere as best as possible to our preregistration, and referred to baseline-standardised results in Appendix table 15.
1) A recent health survey among 6652 older adults showed that moderate and high physical activity was associated with 15%-30% lower likelihoods of loneliness and social isolation and with 27% to 150% higher protective factors. In addition, physical activity was associated with the mitigation of increased healthcare expenditures related to loneliness, social isolation, and low levels of protective factors . Physical activity has been linked to better structural and functional brain health .
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