More work is needed to see if this type of imaging could be used to diagnose the condition early or measure the effectiveness of new treatments.
As Alzheimer’s gets worse over time, plaques and tangles of proteins build up in the brain. These are thought to eventually cause the loss of connections between nerve cells, called synapses. Researchers think that this decrease in synaptic density causes the progressive symptoms of the disease. Researchers led by Drs. Adam Mecca and Christopher van Dyck from Yale University examined 45 people between the ages of 50 and 85 in a new study of this tracer. The participants had early-stage Alzheimer’s, identified by cognitive testing and imaging of plaque buildup in the brain.
The team then compared the associations between test scores and cognitive density as measured by the PET scans. The study was funded in part by NIH’s National Institute on Aging . Results were published on February 17, 2022, inFor all major areas of cognition tested, synaptic density predicted performance. That is, people with reduced synaptic density had lower test scores.
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