By Neha MathurJun 18 2023Reviewed by Benedette Cuffari, M.Sc. In a recent article published in Nature, researchers evaluate the T-cell modulating effects of St. John’s wort, valerian, hops, lavender, and California poppy.
Conventional therapy, antidepressants, selective serotonin reuptake inhibitors like paroxetine, and benzodiazepines for NMDs could disturb the delicate immunological balance of fetal tolerance and protection of mother and child. Thus, changes in T-cell activity are needed for a successful pregnancy.
About the study In the present study, researchers obtained peripheral blood mononuclear cells from healthy donors. PBMCs were then treated with extracts and pure compounds in a culture medium at concentrations of 0.03–100 µg/mL and 0.01-30 µM, respectively. Results The current study evaluated the safety of St. John’s wort, hops, valerian, lavender, and California poppy and their compounds protopine, hyperforin and hypericin, valerenic acid, valtrate, and linalool. The impact of these agents on the viability and function of primary human lymphocytes was also determined.
Valerenic acid, protopine, and linalool showed no marked effects on the function of T-cells, including their viability, proliferation, induced apoptosis, or genotoxicity. Comparatively, hyperforin, hypericin, and valtrate induced apoptosis, as well as inhibited viability and cell division at 3.0 µM.
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