Mastering the Longevity Code: “Immune Resilience” Is Key to Resisting Disease and Living Longer

A groundbreaking research study introduces the concept of “immune resilience.” This term represents the ability to withstand or bounce back from infections and inflammatory stressors. Using novel metrics, the team quantified the varying degrees of immune resilience amongst individuals, finding that it is not solely age-dependent and can affect lifespan and health outcomes.

“Immune resilience is the capacity to maintain good immune function, called immunocompetence, and minimize inflammation while experiencing inflammatory stressors,” said Weijing He, MD, co-author and senior research scientist at the VA Center for Personalized Medicine and Foundation for Advancing Veterans’ Health Research. “We found that during aging and when experiencing inflammatory stress, some persons resist degradation of immune resilience.

“Many people think of inflammation alone when considering disease outcomes,” explained co-author Grace C. Lee, PharmD, PhD, research investigator at the VA Center for Personalized Medicine and assistant professor at The University of Texas at Austin College of Pharmacy. “However, the concept of immune resilience captures levels of immunocompetence and inflammation together.

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