The study was performed in accordance with the Helsinki Declaration’s ethical principles for medical research and was approved by the Regional ethical review board in Linköping . All participants signed informed consent.TO has received honoraria for advisory boards/lectures from Biogen, Merck, Novartis and Sanofi. The same companies have provided unrestricted MS research grants, none of which has dealt with the current manuscript.
Shown are the correlation between gene countsand the beta values of all detected CpGsfor the comparisons 3rd-2nd trimester and 2nd -1st trimester for resting CD4cells in women with MS and HC. Pearson’s correlation r is shown in the individual graphs for each comparison. All correlations had a p < 2.2 x 10and CD8T cells from women with MS and healthy controlswere analyzed by RNA-seq and Infinium MethylationEPIC 850K for DNA methylation.
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