, using as input the human ortholog genes of the up- and downregulated gene signatures post treatment with CLD or GBZ . Negative Z-scores indicate better survival in the high expression group per signature., Boxplots highlighting statistically significant differences between high and low expression of the Post_Up and Post_Down gene signatures across a set of immune parameters calculated for TCGA . Groups were selected based on median expression of Post_Up or Post_Down signatures.
, Progression of MC38-OVA colon carcinomas in mice treated with drinking water supplemented with clonidine ., Phagocytic activity of TME macrophages from mice after 7 days of treatment as in . Data from one representative out of three independent experiments. P values determined by ordinary two-way ANOVA and, Model of the identified mechanisms underlying the anti-tumour activity of α2-AR agonists in the context of immunotherapy.
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