knock-in mouse model of HD . Longitudinal assessment of motor and cognitive functions from 6 to 15 months of age reveals that
deletion also rescues neuronal loss likely via the activation of Akt and ERK1/2 in the striatum ofmice is accompanied by a reduction in the number of nuclear mutant huntingtin aggregates with no change in the total aggregate levels or microgliosis. Collectively, these findings provide novel evidence that
's role in HD remains unclear. We report here that deletion of the gene rescues the deficits in both motor and cognitive functions in HD mice of both sexes. We also find that
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Huntington’s Disease patient says behaviour can 'be mistaken for drunkenness'Darran recently won a prize at St Andrew's Healthcare 2023 Annual Awards in Northampton
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Prevalence and risk factors of significant persistent pain symptoms after critical care illness: a prospective multicentric study - Critical CareBackground Prevalence, risk factors and medical management of persistent pain symptoms after critical care illness have not been thoroughly investigated. Methods We performed a prospective multicentric study in patients with an intensive care unit (ICU) length of stay ≥ 48 h. The primary outcome was the prevalence of significant persistent pain, defined as a numeric rating scale (NRS) ≥ 3, 3 months after admission. Secondary outcomes were the prevalence of symptoms compatible with neuropathic pain (ID-pain score | 3) and the risk factors of persistent pain. Results Eight hundred fourteen patients were included over a 10-month period in 26 centers. Patients had a mean age of 57 (± 17) years with a SAPS 2 score of 32 (± 16) (mean ± SD). The median ICU length of stay was 6 [4–12] days (median [interquartile]). At 3 months, the median intensity of pain symptoms was 2 [1–5] in the entire population, and 388 (47.7%) patients had significant pain. In this group, 34 (8.7%) patients had symptoms compatible with neuropathic pain. Female (Odds Ratio 1.5 95% CI [1.1–2.1]), prior use of anti-depressive agents (OR 2.2 95% CI [1.3–4]), prone positioning (OR 3 95% CI [1.4–6.4]) and the presence of pain symptoms on ICU discharge (NRS ≥ 3) (OR 2.4 95% CI [1.7–3.4]) were risk factors of persistent pain. Compared with sepsis, patients admitted for trauma (non neuro) (OR 3.5 95% CI [2.1–6]) were particularly at risk of persistent pain. Only 35 (11.3%) patients had specialist pain management by 3 months. Conclusions Persistent pain symptoms were frequent in critical illness survivors and specialized management remained infrequent. Innovative approaches must be developed in the ICU to minimize the consequences of pain. Trial registration. NCT04817696. Registered March 26, 2021.
Source: BioMedCentral - 🏆 22. / 71 Read more »
Rob Burrow's wife reveals they have shunned carers as she carries him aroundThe former Rugby League star, who has motor neurone disease, and his wife are showcasing the realities of living with MND
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Man to carry 100 kg up Ben Nevis in world record attemptA MAN from Uddingston will scale Britain’s highest mountain while carrying 100 kg on his shoulders to fundraise for ending motor neuron disease…
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