Comparison Between Dimethyl Fumarate, Fingolimod, and Ocrelizumab After Natalizumab Cessation

Is there any difference in the effectiveness and treatment persistence between dimethyl fumarate, fingolimod, and ocrelizumab among patients with relapsing-remitting multiple sclerosis who switched from natalizumab?In this cohort study, including 1386 patients with RRMS who ceased natalizumab, a switch to ocrelizumab was associated with the lowest annualized relapse rate and discontinuation rates and the longest time to first relapse compared with dimethyl fumarate and fingolimod.

Secondary outcomes were confirmed disability accumulation, disability improvement, and subsequent treatment discontinuation, with the comparisons for the first 2 limited to fingolimod and ocrelizumab due to the small number of patients taking dimethyl fumarate. The associations were analyzed after balancing covariates using an inverse probability of treatment weighting method.

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Study suggests exercise may help counteract genetic risk of type 2 diabetesNew research has revealed being active could lower the risk of type 2 diabetes, even in people with a high genetic risk of developing the medical condition.
Source: medical_xpress - 🏆 101. / 51 Read more »

Can exercise ease anxiety? Study investigates the potentials and pitfalls of fitness as therapyA comprehensive analysis of 25 clinical trials on exercise interventions reveals inconclusive and negative results regarding its efficacy in treating anxiety disorders. Methodological limitations indicate exercise is not currently an effective intervention for anxiety.
Source: NewsMedical - 🏆 19. / 71 Read more »