Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease - Nature Medicine

📆 5/31/2023 12:45 PM
📰 NatureMedicine

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Cross-sectional and longitudinal analyses of tau pathology in preclinical Alzheimer’s disease reveal that tau tangles accumulate as a function of amyloid-β burden only in individuals positive for an astrocyte reactivity biomarker.

We thank all TRIAD, MYHAT and Pittsburgh studies personnel for their effort and participants for their time, data and specimens.

Graduate Program in Biological Sciences—Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilDepartment of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, SwedenCentre for Age-Related Medicine, Stavanger University Hospital, Stavanger, NorwayDepartment of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UKGallen Triana-Baltzer & Hartmuth C.

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