Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance - Nature Medicine

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A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.

This study was supported in part by the National Institutes of Health/NCI grants R01CA266280 , U01CA264583 , the start-up research fund and the University Cancer Foundation via the Institutional Research Grant Program at the University of Texas MDACC and The Break Through Cancer Foundation , the Cancer Prevention and Research Institute of Texas awards RP200385 , RP220101 and RP150079 , research funding from Johnson and Johnson Lung Cancer Initiative , the DOD team grants CA160445 and CA200990 ,...

Yanshuo Chu, Enyu Dai, Yating Li, Guangchun Han, Guangsheng Pei, Minghao Dang, Ruiping Wang, Dapeng Hao, Fuduan Peng, Xinmiao Yan, Yunhe Liu, Shaojun Zhang, Andrew Futreal, Alexander J. Lazar, Michael Green & Linghua Wang Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Davis R. Ingram, Ansam Sinjab, Pravesh Gupta, Rossana Lazcano, Krishna Bhat, Alexander J. Lazar & Humam Kadara Tumour Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, London, UKDepartment of Gastric Surgery, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, ChinaInstitute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, ChinaDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Lymphoma and Myeloma, The...

 

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