We calculated the frequency and rate per 1,000 person-years of severe COVID-19 outcomes for all demographic and clinical factors. Generalized linear models assuming a Poisson distribution with person-time as an offset representing the time at risk were used to derive rate ratios with 95% CIs for the association between demographic and clinical factors and COVID-19-related hospitalization or death.
Individuals with severe obesity who attended the obesity clinic at Cambridge University Hospitals NHS Trust and had received two doses of COVID-19 vaccination between December 2021 and May 2022 were invited to take part. Individuals with acquired or congenital immune deficiencies and cancer were excluded. Third-dose vaccinations ) were administered as part of the NHS vaccination program. UK Health Security Agency policy recommends the use of longer needles in individuals with severe obesity.
Clinical and immunological measurements were taken before the booster vaccination and 8 d , 28 d and 105 d after vaccination. Third-dose vaccinations were administered as part of the NHS vaccination program and were mRNA vaccines ). Clinical data regarding comorbidities associated with obesity were obtained from the medical records. Supplementary Data Tabledetails the demographic characteristics of this cohort.
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Source: NatureMedicine - 🏆 451. / 53 Read more »