has discovered a new brain regulation mechanism that plays a crucial role in producing the proper proteins that maintain optimal brain health. The malfunctioning of this mechanism may be an early contributor to Alzheimer’s disease.
Tip60’s novel function is a critical piece in the brain puzzle that brings us one step closer to understanding the big picture behind Alzheimer’s Disease. Credit: Image was generated using BioRender. The researchers found that restoring depleted amounts of Tip60 in Alzheimer’s models, not only rescues gene activation, but also partially protects against splicing disruptions — demonstrating that the Tip60 enzyme can be a drug target to protect against two different processes that go awry in Alzheimer’s.
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