Associations between cardiovascular risk factors, disease activity and cardiorespiratory fitness in patients with inflammatory joint disease: a cross-sectional analysis - BMC Sports Science, Medicine and Rehabilitation

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A study in published BMCSportsSciMedRehabil finds that age, fat mass and physical activity level are associated with cardiovascular risk factors in patients with inflammatory joint disease. The authors suggest the need for continued exercise intervention.

]. Aforementioned studies have employed various measures of CRF and there is a need to replicate study results using the CRF criterion method. Uncovering associates of CRF in IJD may aid healthcare practitioners in identifying patients that can benefit from a CRF assessment to provide a more comprehensive assessment of CVD risk.

The primary aim of this paper was, therefore, to investigate factors that may associate with CRF in a contemporary IJD population. We hypothesized that we would uncover associations between classical CVD risk factors, disease activity and CRF in patients with IJD. The second objective was to evaluate CRF in patients with IJD relative to reference data from the general population, and explore potential differences in demographic, cardiovascular and IJD-related factors in patients with normal versus low levels of CRF.The data underlying this paper stems from baseline visits in the ExeHeart trial ; a randomized controlled trial with a primary aim to evaluate the effect of high-intensity interval training on CRF in patients with IJD [].

Patients were recruited from the Preventive Cardio-Rheuma Clinic, Center for treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Norway. Patients presenting with an IJD diagnosed by rheumatologist, age 18–70 years, body mass index 18.5–40, ability to walk unaided for ≥ 15 min and Norwegian or English fluency were eligible for inclusion.

] and prior participation in high-intensity interval training ≥ 1/week in the past 3 months. Baseline study visits were carried out from August 2021 to August 2022.Medical background information including IJD diagnosis and co-morbidities were collected from the patient’s medical record. CRF was assessed by a cardiopulmonary exercise test on a treadmill. A modified Balke [] continuous ramp protocol was applied with initial speed individualized to the patient’s preference.

 

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