) have studied the effect of aerobic exercise on cytokine levels. However, to the best of our knowledge, there is no research data on immune cell mobilization in this patient group. It is important to study the biological mechanisms of acute exercise in cancer patients, as findings from such studies may be of importance when designing larger clinical trials.
Consequently, the aim of this study was to determine whether acute exercise mobilizes immune cells, and if so which subpopulations, in the circulation of lymphoma patients.This study was conducted at the Turku PET Centre, Turku, Finland between September 2020, and July 2021. Patients participated voluntarily by signing an informed consent form after reviewing the study information sheet and hearing an explanation about the study from the investigators.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
Health Health Latest News, Health Health Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Classifying cancer cells to predict metastatic potentialCancer cells that initiate metastasis, or the spread of the disease from its primary location, are different from cancer cells that stay in the original tumor. Distinguishing metastasis-initiating cell types can determine the severity of cancer and help medical practitioners decide on a course of treatment.
Source: medical_xpress - 🏆 101. / 51 Read more »
Altered expression of anti-apoptotic protein Api5 affects breast tumorigenesis - BMC CancerBackground Apoptosis or programmed cell death plays a vital role in maintaining homeostasis and, therefore, is a tightly regulated process. Deregulation of apoptosis signalling can favour carcinogenesis. Apoptosis inhibitor 5 (Api5), an inhibitor of apoptosis, is upregulated in cancers. Interestingly, Api5 is shown to regulate both apoptosis and cell proliferation. To address the precise functional significance of Api5 in carcinogenesis here we investigate the role of Api5 in breast carcinogenesis. Methods Initially, we carried out in silico analyses using TCGA and GENT2 datasets to understand expression pattern of API5 in breast cancer patients followed by investigating the protein expression in Indian breast cancer patient samples. To investigate the functional importance of Api5 in breast carcinogenesis, we utilised MCF10A 3D breast acinar cultures and spheroid cultures of malignant breast cells with altered Api5 expression. Various phenotypic and molecular changes induced by altered Api5 expression were studied using these 3D culture models. Furthermore, in vivo tumorigenicity studies were used to confirm the importance of Api5 in breast carcinogenesis. Results In-silico analysis revealed elevated levels of Api5 transcript in breast cancer patients which correlated with poor prognosis. Overexpression of Api5 in non-tumorigenic breast acinar cultures resulted in increased proliferation and cells exhibited a partial EMT-like phenotype with higher migratory potential and disruption in cell polarity. Furthermore, during acini development, the influence of Api5 is mediated via the combined action of FGF2 activated PDK1-Akt/cMYC signalling and Ras-ERK pathways. Conversely, Api5 knock-down downregulated FGF2 signalling leading to reduced proliferation and diminished in vivo tumorigenic potential of the breast cancer cells. Conclusion Taken together, our study identifies Api5 as a central player involved in regulating multiple events during breast carcinogenesis includi
Source: BioMedCentral - 🏆 22. / 71 Read more »
Chances of eliminating HIV infection increased by novel dual gene-editing approachGene-editing therapy aimed at two targets—HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells—can effectively eliminate HIV infection, new research from the Lewis Katz School of Medicine at Temple University and the University of Nebraska Medical Center (UNMC) shows. The study, published online in the journal Proceedings of the National Academy of Sciences (PNAS), is the first to combine a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.
Source: medical_xpress - 🏆 101. / 51 Read more »