Ibogaine inspires new compounds to treat addiction, depression

"Some people swear by ibogaine for treating addiction, but it isn't a very good. It has bad side effects, and it's not approved for use in the U.S.," said Brian Shoichet, Ph.D., co-senior author and professor in the UCSF School of Pharmacy."Our compounds mimic just one of ibogaine's many pharmacological effects, and still replicate its most desirable effects on behavior, at least in mice.

Docking involves systematically testing virtual chemical structures for binding with a protein, enabling scientists to identify new drug leads without having to synthesize them in the lab. Ibogaine is found in the roots of the iboga plant, which is native to central Africa, and has been used for millennia during shamanistic rituals. In the 19th and 20th centuries, doctors in Europe and the U.S. experimented with its use in treating a variety of ailments, but the drug never gained widespread acceptance and was ultimately made illegal in many countries.

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