To determine whether there is a residual risk for breast cancer following bariatric surgery for obesity, the investigators analyzed clinical and administrative data collected between 2010 and 2016 in Ontario. They retrospectively matched women with obesity who underwent bariatric surgery with women without a history of bariatric surgery. Participants were matched by age andstatus. Covariates included diabetes status, neighborhood income quintile, and measures of healthcare use.
In the overall population, 659 cases of breast cancer were diagnosed in the overall population during the study period. This total included 103 cancers in the surgical cohort; 128 in the group with BMI <25; 143 among those with BMI 25–29; 150 in the group with BMI 30–34; and 135 among those with BMI ≥35.
There was an increased hazard for incident breast cancer in the nonsurgical group compared with the postsurgical group after washout periods of 1 year , 2 years , and 5 years . Nevertheless, Doumouras said,"the interaction between the surgery and individuals is poorly studied, and this level of personalized medicine is simply not there yet. We are working on developing a prospective cohort that has genetic, protein, and microbiome [data] to help answer these questions."carriers to study at this point, he added."This is where more patients and time will really help the research process.
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