History of cryptorchidism was defined as having undergone a surgical correction and the information on operation of cryptorchidism was retrieved from the register of procedures, which is part of the National Patient Register. History of any unspecified congenital malformation was also retrieved from the National Patient Register . Data on specific congenital malformations was not available.
Thereafter, we used Kaplan–Meier failure curves and cumulative incidence functions to visualise the differences in mortality. Cox regression models were used to estimate hazard ratios and 95% CI to assess the association between psychiatric comorbidity and all-cause and TGCT-specific mortality. We constructed two multivariable models, in the first model we adjusted for age, index year and education, the second model was further adjusted for cancer stage.
Table 1 Characteristics of cancer patients in subgroups of patients with non-seminoma and seminoma and the matched general population controls.A history of any psychiatric disorder overall was present in 8.8% of the patients and 8.3% of the controls indicating no significant increased risk of TGCT . Comparing TGCT overall to controls revealed no statistically significant differences in proportions of psychiatric disorders. This was also the case for the subgroup of non-seminoma patients.
However, neurodevelopmental disorders were seen among 1.1% of the seminoma patients and among 0.7% of their controls and psychotic disorders were seen among 0.6% of the seminoma patients and among 1.0% of their controls. History of a neurodevelopmental disorder was associated with an increased risk of seminoma whereas a history of a psychotic disorder was associated with a decreased risk of seminoma .
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