No Survival Benefit to Radiation Add-on in Endometrial Cancer

Chemotherapy is the mainstay of treatment for high-risk endometrial carcinoma, and it looks to stay that way, as adding radiation on top does not improve survival over that seen with chemotherapy alone, according to new findings.

The findings were presented at the Society of Gynecologic Oncology Annual Meeting on Women's Cancers 2023. Five-year survival ranges from 50% to 70%, as these patients have a high risk of recurrence, both local and systemic . The study involved 813 patients with surgical stage III or IVA endometrial carcinoma of any histologic subtype. They were randomly assigned to receive either chemoradiotherapy or chemotherapy alone.

At 60 months, the percentage of patients alive and relapse free was 59% in the chemoradiotherapy group and 58% in the chemotherapy-only group .

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