e, f). These findings suggest potential correlations between longitudinal changes in CSTs and effectiveness of therapy.a
, Nonmetric multidimensional scaling analysis of amplicon sequencing variants of all samples, indicating that all samples could be assigned to one of three community state types .Bacterial CSTs over time in individual patients before, during and after nCCRT. Patients were categorized in terms of response .Overview of CST proportions in patients with good response to nCCRT and poor response to nCCRT . * 0.2– ≤ − 0.2. The two grey circles indicate correlation coefficient radii at 0.5 and 1.0.
To further investigate the relationship between bacterial diversity, immune panel, and treatment response, candidate microbes and immune cells and immunomodulatory proteins were selected to construct a predictive LASSO model at the before-nCCRT and during-nCCRT timepoints.
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