By Dr. Sanchari Sinha Dutta, Ph.D.Mar 30 2023Reviewed by Danielle Ellis, B.Sc. A study published in Cell Reports Medicine describes that coronavirus disease 2019 vaccines induce strong T cell response in blood cancer patients, irrespective of antibody response and B cell numbers.
In the current study, scientists have evaluated the dynamics of COVID-19 vaccine-induced immune responses in patients with blood diseases and treatments intended to impair B-cell immunity. In contrast, 100% seropositivity was observed among healthy individuals after the second and third doses. These findings indicate that a small percentage of patients fail to develop robust antibody responses even after three-dose vaccination.
In response to vaccination, healthy individuals exhibited prototypical antibody-secreting cells and T-follicular helper responses. In contrast, prolonged ASCs and skewed Tfh2/17 responses were observed in patients with blood cancers.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
Health Health Latest News, Health Health Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
RIPK3 controls MAIT cell accumulation during development but not during infection - Cell Death & DiseaseStudy: Keeping Tcells active, but not too active, could be key to new immune therapies Hudson_Research
Source: medical_xpress - 🏆 101. / 51 Read more »
A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis - Cancer Cell InternationalBackground Metastasis is the leading cause of mortality in patients with breast cancer (BC). Studies demonstrate that circular RNAs (circRNAs) were involved in BC progression, while the molecular mechanisms remain largely unclear. Methods The microArray circRNA profiles were used to explore the differential expression circRNAs in BC and paracancerous normal tissues, and the quantitative reverse transcription-polymerase chain reaction was used to validate their expression level in clinical samples and cell lines. Nuclear/cytosolic fractionation and fluorescence in situ hybridization (FISH) assays were performed to examine circRRM2 (hsa_circ_0052582) subcellular location. The scratch wound healing and transwell assays were conducted to evaluate the impact of circRRM2 on BC cell migration and invasion. We predicted miRNAs that might bind with cricRRM2 and the downstream target genes using bioinformatics analysis and explored their expression levels and prognostic value in BC. FISH, RNA immunoprecipitation, Co-immunoprecipitation, Western blot, and rescue experiments were implemented to figure out circRRM2 function and underlying mechanisms in BC. Results The present study revealed several aberrant circRNAs in BC tissues and observed that circRRM2 was upregulated in tumor tissues of 40 patients with BC. High circRRM2 was significantly associated with advanced N stage in patients with BC. Gain- and loss- of function experiments revealed that circRRM2 promoted the migration and invasion of cells and functioned as an oncogene in BC. Mechanism studies showed that circRRM2 competed with miR-31-5p/miR-27b-3p to upregulate the IGF2BP1 expression. Furthermore, IGF2BP1 upregulated the circRRM2 level via interacting with MYC, which functioned as the transcriptional factor of circRRM2. Thus, the positive feedback loop that was composed of circRRM2/IGF2BP1/MYC was identified. Conclusion This study confirms that upregulated circRRM2 functions an oncogenic role in BC metastasis. The
Source: BioMedCentral - 🏆 22. / 71 Read more »
Murderer found dead in prison cell at HMP Shotts took his own lifeAn inquiry into the death of killer Brian Connor heard that he had a history of mental ill-health, but showed no signs of being suicidal in the weeks before his death.
Source: Glasgow_Live - 🏆 4. / 97 Read more »
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas - Nature MaterialsA hydrogel-based modular lymphoma organoid identifies how lymphoid microenvironment cues dampen the effect of MALT1 inhibitors and informs effective combination therapies to rescue the treatment response
Source: medical_xpress - 🏆 101. / 51 Read more »