Beethoven's death: Whole-genome sequencing from hair reveals Hepatitis B

virus in, at the latest, the months before the composer's final illness. Those likely contributed to his death," he disclosed.

The Stumpff Lock in a laboratory at the Max Planck Institute for the Science of Human History, Germany.The researchers point out that prior studies that suggested Beethoven had lead poisoning were based on a sample that wasn't even Beethoven's. Instead, it was from a female. They argue that future investigations looking for lead, opiates, and mercury must be based on reliable samples.

Also, Krause's team found that none of the five modern relatives with the same last name as Beethoven, who have a common ancestor with his paternal line , share the same Y chromosome.This discovery suggests an extramarital 'event' on Beethoven's father's side somewhere along the generations, according to Tristan Begg, currently a professor at the University of Cambridge, U.K.

"Together with the genetic predisposition and his broadly accepted alcohol consumption, these present plausible explanations for Beethoven's severe liver disease, which culminated in his death," stated the team. They conclude that further research on Beethoven's samples, which were gathered over time, may help to determine when he contracted hepatitis B. Besides that, new research on his near relatives could also shed light on his biological connection to modern Beethoven descendants.Ludwig van Beethoven remains among the most influential and popular classical music composers.

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