The study explored the impact of a specific cellular mechanism on physical fitness improvement through exercise training. It also discovered an anti-aging intervention that could slow down the aging-related declines in the model organism.Exercise has been demonstrated to shield against numerous diseases and is considered a potent anti-aging intervention by science. Despite its ability to enhance health in older individuals, its positive effects eventually diminish.
“As we perceive that our muscles undergo a pattern of fatigue and restoration after an exercise session, they are undergoing this mitochondrial dynamic cycle,” said Blackwell, who is also acting section head of Immunobiology at Joslin. “In this process, muscles manage the aftermath of the metabolic demand of exercise and restore their functional capability.”
“We determined that a single exercise session induces a cycle of fatigue and physical fitness recovery that is paralleled by a cycle of the mitochondrial network rebuilding,” said first author Juliane Cruz Campos, a postdoctoral fellow at Joslin Diabetes Center. “Aging dampened the extent to which this occurred and induced a parallel decline in physical fitness.
Secret of actin needs unlocking as root cause of aging & common diseases CrackingNaturesCode explores exciting potential p.22