By Dr. Chinta SidharthanMar 7 2023Reviewed by Aimee Molineux In a recent study published in the journal Brain, Behavior, & Immunity - Health, researchers conducted a prospective population survey, functional brain imaging, and a cognitive task performance test to determine whether a history of symptomatic coronavirus disease 2019 was associated with psychiatric and neurocognitive symptoms.
About the study In the present study, the researchers used a series of cognitive tasks involving the processing of information and executive function, and decisions making and employed functional near-infrared spectroscopy to determine the task-related functional activation. Functional near-infrared spectroscopy is a suitable technique to study brain health in relation to COVID-19 as it can quantify the oxygen saturation in different parts of the brain related to functional activation.
A 10-item scale from the Centers for Epidemiological Studies to assess depression, a seven-item scale to evaluate generalized anxiety disorder, and a three-item measure of agitation symptoms was used to investigate the psychiatric symptoms. Furthermore, self-reported sex, age, and ethnicity were used as demographic covariates and moderators in the analysis.
Delay discounting was also amplified in individuals with a history of symptomatic COVID-19. Delay discounting tasks are associated with the orbitofrontal cortex. These findings are significant as this region of the brain is thought to be the primary neuroinvasion and neuroinflammation site of SARS-CoV-2.
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