Amyloid Gains Converts in Debate Over Alzheimer’s Treatments

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The success of Eisai’s new Alzheimer's drug Leqembi has helped quiet a debate on whether removing amyloid from the brain can aid in slowing deterioration. “It isn’t really a hypothesis anymore.”

Dispute has far-reaching consequences, including whether Medicare will pay for new anti-amyloid drugs

Biogen’s Aduhelm is the first approved treatment for early-stage Alzheimer’s patients that might be able to slow the disease. WSJ explains how the drug interacts with brain cells, and why some doctors aren’t ready to prescribe it. Illustration: Jacob ReynoldsThe success of Eisai Co. ’s new Alzheimer’s drug has helped quiet a decadeslong dispute over a leading theory of what causes the disease and how to treat it, with proponents declaring victory and some former skeptics switching sides.

Since the early 1990s, many scientists have thought that removing clumps of a sticky protein called amyloid from the brains of Alzheimer’s patients could help slow the disease, if not stall or reverse it. The theory was an outgrowth of the “amyloid hypothesis,” which held that an abnormal accumulation of brain amyloid was the central trigger in a complex neurodegenerative process leading to Alzheimer’s.

 

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Possibly try a tnf blocker?

Quick, get some of this to Biden.

Google translate. “Someone was offered a board seat of two and suddenly the drug is a miracle without peer.”

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