. We also acknowledge the contributions of Jeremy Harper, Farrukh Koraishy, Kellie Walters, Leonie Misquitta, and David Sahner.This research was funded by the National Institutes of Health Agreement OT2HL161847-01. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the NIH.
The analyses described in this publication were conducted with data or tools accessed through the NCATS N3C Data Enclave covid.cd2h.org/enclave and supported by NCATS U24 TR002306.
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Long non-coding RNA signature in colorectal cancer: research progression and clinical application - Cancer Cell InternationalColorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are associated with aberrant expression of multiple coding and non-coding genes. Long non-coding RNAs (lncRNAs) have an important role in regulating gene stability as well as gene expression. Numerous current studies have shown that lncRNAs are promising biomarkers and therapeutic targets for colorectal cancer. In this review, we have searched the available literature to list lncRNAs involved in the pathogenesis and regulation of colorectal cancer. We focus on the role of lncRNAs in cancer promotion or suppression, their value in tumor diagnosis, and their role in treatment response and prognosis prediction. In addition, we will discuss the signaling pathways that these lncRNAs are mainly associated with in colorectal cancer. We also summarize the role of lncRNAs in colorectal precancerous lesions and colorectal cancer consensus molecular subgroups. We hope this review article will bring you the latest research progress and outlook on lncRNAs in colorectal cancer.
Source: BioMedCentral - 🏆 22. / 71 Read more »
Higher anxiety and perceived trauma among COVID-19 patients: a prospective comparative study - BMC PsychiatryBackground and purpose Psychiatric disorders such as anxiety, depression, and traumatic stress are not rare during infectious outbreaks, as the COVID-19 pandemic has posed a great concern to the general population. In this study, we aimed to investigate whether experiencing psychiatric symptoms during COVID-19 is the result of the burden of carrying an illness or the COVID-19 itself. Method Two hundred ten subjects and three different groups of participants (COVID-19 patients, university staff, and orthopedic patients) were recruited. They answered a demographic questionnaire, Yale-Brown Obsessive–Compulsive Scale (YBOCS) test for OCD symptoms, Impact of Event Scale-Revised (IES-R) for perceived trauma, Beck Anxiety Inventory (BAI) for anxiety, and Beck Depression Inventory (BDI) for depression assessments using phone or face-to-face interviews. Result At least one OCD symptom was observed in 85.7% of the subjects. However, there was no significant difference between the 3 groups (p = 0.2194). Perceived trauma was significantly higher among COVID-19 patients followed by university staff and orthopedic patients (23.73, 16.21, 11.51 mean IES-R scores respectively, p = 8.449e−14). COVID-19 patients also showed higher anxiety (mean BAI score: 17.00) than the university staff and orthopedic patients’ group (9.22 and 5.56 respectively) (p = 6.175e−08). BDI score did not show much variation for depression, the mean score was 9.66, 9.49, and 6.7 for the COVID-19 patients, university staff, and orthopedic patients respectively, (p = 0.2735). Conclusion Perceived trauma and anxiety symptoms are significantly higher in COVID-19 patients and the symptoms of OCD and depression do not differ between COVID-19 and non-COVID-19 people, so the necessity of screening and following treatment of patients with COVID-19 should be kept in mind. Trial registration IR.IUMS.FMD.REC.1399.761.
Source: BioMedCentral - 🏆 22. / 71 Read more »
Research examines antibiotic use during COVID-19 by ageIn a research letter published in JAMA Health Forum, researchers evaluated antibiotic prescriptions during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-associated health visits in outpatient settings by United States (US) residents aged ≤64 years who have commercial health insurance.
Source: NewsMedical - 🏆 19. / 71 Read more »
Mum given months to live after doctors blamed cancer symptoms on Covid jabMum given months to live after doctors wrongly blamed cancer symptoms on Covid jab and told her she had an STI
Source: MENnewsdesk - 🏆 23. / 69 Read more »
Celebrity tweets likely shaped US negative public opinion of COVID-19 pandemic, finds studyTweets by people in the public eye likely increasingly shaped negative public opinion of the COVID-19 pandemic as it progressed in the US, suggests an analysis of sentiments expressed in social media posts, published in the open access journal BMJ Health & Care Informatics. physorg_com It's a sad commentary on a large chunk of our population that they had no concept of checking their sources. Science by popular vote?
Source: medical_xpress - 🏆 101. / 51 Read more »