Prior COVID highly protective against severe disease ten months post-infection

They meta-analyzed the gathered data to determine the effectiveness of a previous SARS-CoV-2 infection in preventing SARS-CoV-2 re-infections, including both symptomatic and severe re-infections . The researchers stratified results by the infecting SARS-CoV-2 variant and time lapsed since the previous infection, as much as possible. Finally, they used a Bayesian meta-regression model to quantify the pooled estimates of protection conferred by a previous SARS-CoV-2 infection.

About the study In the present study, researchers searched peer-reviewed publications, reports, preprints, medRxiv, and news articles in databases, such as PubMed, medRxiv, and Web of Science using keywords, such as SARS-CoV-2, a previous or past infection, natural immunity, or re-infection. The researchers defined study outcome, re-infection as a positive RT-PCR/ RAT more than 90 days after a past positive test, two positive tests after four negative tests, or a positive PCR/RAT with a positive antibody test. Likewise, they defined symptomatic re-infection as re-infection with SARS-CoV-2 that leads to new onset of symptoms and severe illness as re-infection that leads to hospitalization or death.

Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Strikingly, although protection from past infection waned over time, the level of protection against all three study outcomes appeared durable, similar in magnitude to the protection provided by a two-dose mRNA vaccination regimen, as illustrated in an unpublished study by Nassereldine H et al.

Moreover, this study had significant policy implications. First, its results suggested that surveillance systems monitoring SARS-CoV-2 re-infections and variant emergence remain relevant as they could help manage current and future transmission. Second, nations should consider restricting travel or access to specific venues based on immune status conferred by vaccination and natural infection.

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