Oncolytic viral therapies induce direct killing of tumor cells and activation of conventional dendritic cells ; however, cDC activation has not been optimized with current therapies. We evaluated adenoviral delivery of engineered membrane-stable CD40L and IFNβ to locally activate cDCs in mouse tumor models.
Combined tumor MEM40 and IFNβ expression induced the highest cDC activation coupled with increased lymph node migration, increased systemic antitumor CD8+ T-cell responses, and regression of established tumors in a cDC1-dependent manner. MEM40+IFNβ combined with checkpoint inhibitors led to effective control of distant tumors and lung metastases.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more: