Frontiers | Prolyl-hydroxylase inhibitor-induced regeneration of alveolar bone and soft tissue in a mouse model of periodontitis through metabolic reprogramming

< 0.01. In , a graph of area of bone growth is seen for mice post–ligature but not given drug vs. mice given drug . Mice were injected with DPCA-PEG subcutaneously on days 0 and 8 after ligature placement and removal. MicroCT scans were obtained on day 15 of the experiment and on day 30 . Here, a statistical analysis of the area of bone growth is seen. Significant differences are found between the no drug control mice and DPCA-PEG-treated mice on day 15 .

In micro-CT data shows a representative mouse maxilla which had ligature removed at day 10, scanned on day 10 and then re-scanned on day 30 as compared to a representative mouse maxilla receiving ligature and DPCA-PEG drug seen on day 10 and day 30 . The level of regrowth in the drug-treated group shows an almost, if not complete, return to what is seen before the start of the experiment . In , there was no change in bone histology approximately 6 months later.

very exciting development.

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Aspirin as effective as blood thinner injections to prevent deadly complications in patients with bone fracturesPatients hospitalized with fractures typically receive an injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots. A new clinical trial, however, found that inexpensive over-the-counter aspirin is just as effective. The findings, published today in the New England Journal of Medicine, may lead surgeons to change their practice and administer aspirin to these patients.
Source: medical_xpress - 🏆 101. / 51 Read more »