, while providing the respective precursor drug as well as oxygen at a de facto unlimited uptake rate of 1,000 mmol per gTo determine species in microbiome models that were of importance for the microbiome’s combined potential to metabolize a drug, a shadow price analysis was performed as described previously. Briefly, shadow prices are a feature of every FBA solution that reflect the contribution of each metabolite in the model to the flux through the objective function.
Drug metabolites with over 50% nonzero entries were analyzed via linear regressions using heteroscedastic robust standard errors. First, we investigated potential effects of basic covariates via generalized linear regressions with the net production capacity being the response variable . Age and BMI were introduced into the models as restricted cubic splinesusing four knots resulting in three spline variables, each to test on potential nonlinear relationships.
Interested in working with AGORA2? I have a PhD position open!
MetExplore GalwayCMNHS RyanInstitute uni_lu CZUvPraze UMCUtrecht LACDR UChicago argonne ines_thiele heinken_almut Awesome job. Will help in future to treat multiple diseases and will improve the developments of personalised medicine.
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Source: NatureBiotech - 🏆 231. / 63 Read more »