By Suchandrima BhowmikJan 18 2023Reviewed by Danielle Ellis, B.Sc. Vitamin D is an essential macronutrient that is involved in several biological processes. Vitamin D production takes place endogenously as vitamin D3 or is obtained from the diet or supplements as vitamin D2 or vitamin D3. The role of vitamin D in preventing osteomalacia and rickets has already been established.
A new study in the journal JAMA Network Open aimed to determine whether BMI is capable of modifying vitamin D metabolism as well as response to supplementation. Information on body weight and height was collected from the participants using a self-reported questionnaire at baseline. Quantifying the total 25-OHD3 and 25-OHD took place using liquid chromatography-tandem mass spectrometry. Measurement of free vitamin D levels took place using polyclonal VDBD and enzyme-linked immunoassay, while intact parathyroid hormone and albumin levels took place using a chemiluminescent-based assay. Quantification of serum calcium levels took place using spectroscopy.