Hearing loss refers to a decline in the ability to hear sounds, either partially or completely. It can be caused by a variety of factors such as exposure to loud noise, aging, infection, and certain medical conditions.
For example, damage to the hair cells in the inner ear can lead to hearing loss. According to Dr. Amrita Iyer, a researcher at, “these cells allow the brain to detect sounds.” Transcription factors promote the expression of certain genes and prevent the expression of others. By changing the pattern of gene expression, the researchers hoped to lead cells to a state in which they would regenerate hair cells in mature animals similar to what happens during development.
To study the structure of the hair cell bundles generated by reprogramming, Iyer collaborated with Dr. Yeohash Raphael’s lab at theto perform scanning electron microscopy imaging on the cochleae of mice conditionally overexpressing these transcription factors. The images clearly showed that the hair cell bundles were in accordance with what is observed on inner hair cells during development.
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