Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population - Nature Medicine

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A serosurvey analysis from January-July 2022 in Hong Kong shows that the effectiveness of COVID19 vaccines against Omicron variant infection waned rapidly after the 3rd and 4th doses SARSCoV2 HKUMed HKU_SPH HKU_D24H

The SARS-CoV-2 Omicron variant has demonstrated enhanced transmissibility and escape of vaccine-derived immunity. While first-generation vaccines remain effective against severe disease and death, robust evidence on vaccine effectiveness against all Omicron infections, irrespective of symptoms, remains sparse.

Jonathan J. Lau, Samuel M. S. Cheng, Kathy Leung, Leo C. H. Tsang, Kenny W. H. Yam, Sara Chaothai, Kelvin K. H. Kwan, Zacary Y. H. Chai, Tiffany H. K. Lo, Eric H. Y. Lau, Gabriel M. Leung, Malik Peiris & Joseph T.

 

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