Anti-hyperglycemic medications are used to lower blood sugar levels in people with high blood sugar, or hyperglycemia. These medications can be used to treat conditions such as diabetes, prediabetes, and gestational diabetes. They work by decreasing the amount of sugar produced by the liver, increasing the sensitivity of muscle and fat cells to insulin, or helping the body use sugar more effectively.
“Our findings reinforce the need for a precision medicine approach to preventing MS in these vulnerable populations,” said lead researcher Kathleen Rodgers, Ph.D., associate director of translational neuroscience at the Center for Innovation in Brain Science. For people with Type 2 diabetes, there is mounting evidence linking metabolic disorders and MS through a common driver of increased autoimmunity. This brings into question the impact of anti-hyperglycemic therapeutics used to treat Type 2 diabetes, including insulin, on the incidence of MS.Alzheimer’s
They found that men older than 45 years old had a slightly significant increase of MS risk and women older than 45 years exhibited a significant increase in MS incidence after anti-hyperglycemic exposure. In addition to age differences, the risk analysis by drug class showed that exposure to insulin in patients older than 45 years old was associated with a greater increased risk compared with other therapies.
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