CAR T cell therapy may eliminate tumor cells missed by surgery

, the researchers applied a special gel containing human CAR T cells to surgical wounds in mice following partial tumor removal. They found that in almost all cases, the CAR T cells apparently eliminated the residual tumor cells—allowing the mice to survive when they otherwise would have succumbed to tumor recurrence.

"As we continue to advance CAR T cell therapy forward, finding applications for use in solid tumors is a major goal," said study senior author Carl June, MD, the Richard W. Vague Professor in Immunotherapy and director of the Center for Cellular Immunotherapies at Penn Medicine's Abramson Cancer Center."Based on the promising results in this study, our colleagues have planned a clinical trial in patients with locally advanced breast cancer.

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Association of shift work with incident dementia: a community-based cohort study - BMC MedicineBackground Some observational studies had found that shift work would increase risks of metabolic disorders, cancers, and cardiovascular diseases, but there was no homogeneous evidence of such an association between shift work and incident dementia. This study aimed to investigate whether shift work would increase the risk of dementia in a general population. Methods One hundred seventy thousand seven hundred twenty-two employed participants without cognitive impairment or dementia at baseline recruited between 2006 and 2010 were selected from the UK Biobank cohort study. Follow-up occurred through June 2021. Shift work status at baseline was self-reported by participants and they were categorized as non-shift workers or shift workers. Among shift workers, participants were further categorized as night shift workers or shift but non-night shift workers. The primary outcome was all-cause dementia in a time-to-event analysis, and the secondary outcomes were subtypes of dementia, including Alzheimer’s disease, vascular dementia, and other types of dementia. Results In total, 716 dementia cases were observed among 170,722 participants over a median follow-up period of 12.4 years. Shift workers had an increased risk of all-cause dementia as compared with non-shift workers after multivariable adjustment (hazard ratio [HR], 1.30, 95% confidence interval [CI], 1.08–1.58); however, among shift workers, night shift work was not associated with the risk of dementia (HR, 1.04, 95% CI, 0.73–1.47). We found no significant interaction between shift work and genetic predisposition to dementia on the primary outcome (P for interaction = 0.77). Conclusions Shift work at baseline was associated with an increased risk of all-cause dementia. Among shift workers, there was no significant association between night shift work and the risk of dementia. The increased incidence of dementia in shift workers did not differ between participants in different genetic risk strata for dementia.
Source: BioMedCentral - 🏆 22. / 71 Read more »

Scientists make progress in decoding genetics of insomniaA research effort involving researchers from Texas A&M University, the Perelman School of Medicine at the University of Pennsylvania and Children's Hospital of Philadelphia (CHOP) has used human genomics to identify a new genetic pathway involved in regulating sleep from fruit flies to humans—a novel insight that could pave the way for new treatments for insomnia and other sleep-related disorders. physorg_com TAMU ScienceAdvances Insomnia is viral. You catch it from your kids. physorg_com TAMU ScienceAdvances So there actually are scientists who believe insomnia is more heavily regulated by genetics than by sleep habits, physical and mental health, diet, exercise and all that good stuff? TAMU ScienceAdvances I wonder if this would help the people who have the genetic disorder where they gradually stop sleeping and die.
Source: medical_xpress - 🏆 101. / 51 Read more »