Review shows metformin usage to be associated with better COVID-19 outcomes

By Pooja Toshniwal PahariaJan 11 2023Reviewed by Aimee Molineux In a recent review published in the Journal of Diabetes and its complications, researchers reported the potential association between metformin usage and coronavirus disease 2019 outcomes.

About the review In the present review, researchers presented reviewed existing literature on the impact of metformin use on SARS-CoV-2 infection outcomes. As a result, metformin could mitigate the COVID-19-associated cytokine storm, an effect reportedly greater among women than men. Furthermore, activated AMPK-induced mTOR or rapamycin inhibition could lower COVID-19 susceptibility and associated mortality.

Among older individuals, metformin usage reduced one-month in-hospital COVID-19-associated mortality and increased the chances of hospital discharge. The protective effects associated with metformin use were more prominent among obese female or T2D patients. Further, studies reported that the most optimum dose of metformin against COVID-19 was one to two grams daily.

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