The World Health Organisation was holding talks in Geneva on Wednesday amid increasing international concern about the accuracy of China's data about the outbreak."the importance of vaccination, including booster doses to protect against hospitalisation, severe disease and death".
"We continue to ask China for more rapid, regular, reliable data on hospitalisations and deaths, as well as more comprehensive, real-time viral sequencing," he said.amid a surge in COVID cases, while in Europe and the US the Omicron subvariant XBB.1.5 is spreading rapidly.is the most transmissible variant so far, but said so far it did not appear to cause more serious illness.
It evolved from the XBB variant of Omicron, itself a fusion of two different BA.2 variants - BA.2.10.1 and BA.2.75. China's recent COVID outbreak is predominantly led by the Omicron subvariants BA.5.2 and BF.7, which together account for 97.5% of all local infections. European Union health officials are also discussing a coordinated response to the situation in China, such as further travel restrictions.
So vx, lockdowns, masks and a constant drone of propaganda didn't work ? 😲 shock horror.
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Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection OutcomesAge-related macular degeneration (AMD) has been implicated as a risk factor for severe consequences from COVID-19. We evaluated the genetic architecture shared between AMD and COVID-19 (critical illness, hospitalization, and infections) using analyses of genetic correlations and pleiotropy (i.e., cross-phenotype meta-analysis) of AMD (n=33,976) and COVID-19 (n ≥ 1,388,342) and subsequent analyses including expression quantitative trait locus (eQTL), differential gene expression, and Mendelian randomization (MR). We observed a significant genetic correlation between AMD and COVID-19 infection (rG=0.10, p=0.02) and identified novel genome-wide significant associations near PDGFB (best SNP: rs130651; p=2.4 × 10−8) in the pleiotropy analysis of the two diseases. The disease-risk allele of rs130651 was significantly associated with increased gene expression levels of PDGFB in multiple tissues (best eQTL p=1.8 × 10−11 in whole blood) and immune cells (best eQTL p=7.1 × 10−20 in T-cells). PDGFB expression was observed to be higher in AMD cases than AMD controls {fold change (FC)=1.02; p=0.067}, as well as in the peak COVID-19 symptom stage (11–20 days after the symptom onset) compared to early/progressive stage (0–10 days) among COVID-19 patients over age 40 (FC=2.17; p=0.03) and age 50 (FC=2.15; p=0.04). Our MR analysis found that the liability of AMD risk derived from complement system dysfunction {OR (95% CI); hospitalization=1.02 (1.01–1.03), infection=1.02 (1.01–1.03) and increased levels of serum cytokine PDGF-BB {β (95% CI); critical illness=0.07 (0.02–0.11)} are significantly associated with COVID-19 outcomes. Our study demonstrated that the liability of AMD is associated with an increased risk of COVID-19, and PDGFB may be responsible for the severe COVID-19 outcomes among AMD patients.
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