expression increased in alveolar type I , AT2, ciliated and neuroendocrine cells in human COPD. RIPK1 protein levels were significantly increased in airway epithelium of COPD patients, compared to never smokers and smokers without airflow limitation. In mice, exposure to cigarette smoke increasedexpression similarly in AT2 cells, and further in alveolar macrophages and T cells.
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Conflict of interest: Tania Maes reports grants from FWO Flanders, Chiesi, GSK; and is a shareholder of Oryzon Genomics, Mendelion Lifesciences SL; outside the submitted work. Conflict of interest: Guy Joos reports consulting fees from GSK, AstraZeneca; lecture honoraria from GSK, AstraZeneca, Novartis, Lapharcon, Eureca vzw; travel support from GSK; and acts as Chair operational Committee IRC for ERS; outside the submitted work.
Conflict of interest: Guy Brusselle reports advisory board participation and lecture honoraria from AstraZeneca, Boehringer-Ingelheim, Chiesi, GlaxoSmithKline, MerchSharp&Dohme, Novartis, Sanofi; outside the submitted work.Received